At HAWK University of Applied Sciences and Arts Hildesheim/Holzminden/Göttingen, Faculty of Engineering and Health, Göttingen campus, the following position in the ERC Advanced Grant project FEMTOMICS is to be filled at the earliest possible date, for a fixed term of three years:

Within the ERC Advanced Grant project FEMTOMICS, we are developing novel photonic and molecular analytical methods for the high-resolution investigation of dynamic protein-DNA interactions. Femtosecond laser-based crosslinking (fliX) is combined with complementary methods in quantitative and structural proteomics (LC-MS/MS), genomics and sequencing (ChIP-Seq, nanopore sequencing), and bioinformatics for multiomics data integration and analysis to characterise protein–DNA interactions at the structural and functional levels. The aim is to make previously inaccessible dynamic molecular processes experimentally measurable and thereby establish new foundations for investigating regulatory mechanisms in biological and disease-relevant systems. A central focus is the development and physicochemical characterisation of novel irradiation and measurement approaches based on ultrashort laser pulses.

For this research area, we are seeking a highly motivated scientist with strong experimental expertise in non-linear optics and ultrashort-pulse laser systems who can independently develop, implement, and characterise complex optical setups and, together with an interdisciplinary team, investigate the underlying femtochemical processes. The work combines fundamental research in ultrafast physics and femtochemistry with applications in molecular bioanalytics and biomedical research. It will open up new opportunities for the structural and functional analysis of protein–DNA interactions and for understanding disease-relevant regulatory processes.